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急性心肌梗死(AMI)是威胁人类健康的重大疾病,心肌梗死(MI)后30 min,部分心肌细胞即发生不可逆的坏死,因此,MI有效救治的时间窗极为短暂,许多患者不能够得到及时有效的治疗,使得MI后心力衰竭(HF)的发生率仍然居高不下。最新调查研究表明,MI后1年HF的发生率约为14.2%。因MI后HF再次入院的患者,1年死亡率高达为45.5%。MI后HF的主要原因是部分心肌细胞坏死,左室重构,心脏扩张,继而引发HF。目前,MI后左室重构的机制尚未完全阐明。本文介绍了AMI后左室重构的发病机制主要进展。
Acute myocardial infarction (AMI) is a serious disease that threatens human health. Some myocardial cells undergo irreversible necrosis 30 minutes after myocardial infarction (MI). Therefore, the effective time window for effective treatment of MI is very short, and many patients can not get timely and effective Of the treatment, making the incidence of heart failure (HF) after MI is still high. The latest research shows that 1 year after MI HF incidence of about 14.2%. One-year mortality rates were 45.5% for HF hospitalized again after MI. HF after MI is mainly due to myocardial necrosis, left ventricular remodeling, cardiac expansion, which in turn lead to HF. At present, the mechanism of left ventricular remodeling after MI has not been fully elucidated. This article describes the major advances in the pathogenesis of left ventricular remodeling after AMI.