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正常胃组织为无雌激素标记的器官,当发生胃癌时,进行雌激素受体(ER)细胞组织化学研究对了解胃癌组织发生增殖、进展与激素环境间关系具有重要意义。作者研究了胃切除术后的原发性胃癌140例病理标本。按PAP 法进行ER 染色。ER 染色标准为在癌细胞总数中ER 阳性癌细胞占50%以上为ER(+),50～10%为ER(±),10%以下为ER(-)。结果显示:(1)胃癌细胞ER 染色性与乳癌细胞比较,胃癌细胞胞核较少,因此,核受体数目亦较
Normal gastric tissue is an estrogen-free organ. When gastric cancer occurs, it is important to perform estrogen receptor (ER) cell histochemical studies to understand the relationship between the proliferation and progression of gastric cancer tissues and the hormonal environment. The authors studied 140 pathological specimens of primary gastric cancer after gastrectomy. The ER staining was performed according to the PAP method. The ER staining standard is that ER-positive cancer cells occupy 50% or more of the total number of cancer cells as ER(+), 50-10% as ER(±), and 10% or less as ER(-). The results showed that: (1) Compared with breast cancer cells, ER staining of gastric cancer cells had less nuclei in gastric cancer cells, and therefore, the number of nuclear receptors was also higher.