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为证实血管紧张素Ⅱ受体阻断剂Ⅰｒ对ＣＨＦ大鼠肌细胞凋亡有预防作用的假说 ,作者用响尾蛇毒蛋白单体 (ｍｏｎｏｃｒｏｔａｌｉｎｅ)按 30ｍｇ·ｋｇ- 1·ｄ- 1注入诱发 36只大鼠ＣＨＦ ,对照组注射生理盐水。 2周后 ,其中 18只大鼠用微型渗透泵输入Ⅰｒ(7ｍｇ·ｋｇ- 1·ｄ -
To confirm the hypothesis that angiotensin II receptor blocker Ir can prevent myocyte apoptosis in CHF rats, we induced 36 rats with monocrotaline 30 mg · kg -1 · d -1 Rats CHF, control group injected with saline. Two weeks later, 18 rats were treated with mini-osmotic pump with Ⅰr (7mg · kg-1 · d-