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目的:探讨活体肾移植留存肾不同肾小球滤过率(GFR)水平对供者术后肾功能恢复、并发症及长期健康的影响。方法:收集西安交通大学第一附属医院1999年10月19日至2018年12月31日512例活体肾移植供者的临床资料。术前应用放射性核素n 99mTC-DTPA肾动态显像法测定供者左、右肾GFR，根据供者术前留存肾GFR结果，将供者分为GFR0.05)。n 结论:活体肾移植供者术后长期安全性良好。对于术前总GFR≥80 ml/min的供者，留存肾GFR影响供者早期肾功能水平，留存肾GFR高的供者术后早期(3个月内)血肌酐水平较低、eGFR水平较高，但留存肾GFR水平不影响供者术后远期肾功能及并发症发生率。“,”Objective:To explore the long-term safety for different levels of glomerular filtration rate (GFR) of retained kidney among living-related donors.Methods:From 1999 to 2018, a total of 512 living donors were recruited and divided into three groups according to the GFR level of donor retained kidney (GFR <45 ml/min; 45 ml/min ≤GFR <50 ml/min; GFR ≥50 ml/min). Health status, postoperative recovery and postoperative complications were compared. GFR was measured by n 99mTC-DTPA. The recovery of kidney function and postoperative complications of donor were evaluated.n Results:After excluding 163 donors because of incomplete data, a total of 349 healthy donors without kidney failure were included. The longest postoperative follow-up time was 20 years and the median follow-up period 8.3 years. No significant difference existed in the incidence of postoperative hypertension and urinary protein among three donor groups. The postoperative serum level of creatinine (Scr) at Week 1, Month 1/3 and Year 3/5/10 was higher in GFR≥50 ml/min group than that in GFR <45 ml/min group and the differences of Scr/eGFR were significantly different at Week 1 and Month 3 ( n P<0.05). And GFR was not significantly different among three donor groups beyond 10 years.n Conclusions:Living-related donors have excellent long-term safety after donation. For donors with preoperative total GFR≥80 ml/min, the level of retained renal GFR affects early renal function recovery while those with high GFR recover faster postoperatively. However, GFR level does not affect long-term donor renal function and complication rate after donation.