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目的探讨Ph染色体阳性急性淋巴细胞白血病(Ph+ALL)与慢性粒细胞白血病急淋变的临床特点。方法对21例Ph+ALL患者及31例慢粒急淋变患者的临床资料进行回顾性对比分析。结果 Ph+ALL与慢粒急淋变有以下区别:①慢粒急淋变肝脾肿大发生率(80.65%)比Ph+ALL(14.28%)高(P<0.05);②起病时慢粒急淋变外周血白细胞数比Ph+ALL高(P<0.05);③Ph+ALL完全缓解率(76.19%)比慢粒急淋变(48.39%)高(P<0.05)。Ph+ALL的中位生存期为(10.76±6.91)个月,而慢粒急淋变的中位生存期为(7.06±6.03)个月,差异有统计学意义(P<0.05)。慢粒急淋变者完全缓解后Ph染色体持续存在,Ph+ALL患者完全缓解后Ph染色体消失。两组患者年龄、性别、骨髓中原始加幼稚细胞数差异均无统计学意义(P>0.05)。结论 Ph+ALL与慢粒急淋变具有不同的临床特点及治疗反应。
Objective To investigate the clinical features of acute lymphoblastic leukemia Ph chromosome (Ph + ALL) and chronic leukemia. Methods The clinical data of 21 Ph + ALL patients and 31 patients with AMI were retrospectively analyzed. Results Ph + ALL had the following differences with CML: ① The incidence of hepatomegaly and splenomegaly of AMI was higher (80.65%) than that of Ph + ALL (14.28%) (P <0.05) The number of acute leukopenia peripheral blood leukocytes was significantly higher than that of Ph + ALL (P <0.05). The complete remission rate of Phh + ALL was higher than that of Ph + ALL (76.19%) (P <0.05). The median survival time of Ph + ALL was (10.76 ± 6.91) months, while the median survival time was 7.06 ± 6.03 months. The difference was statistically significant (P <0.05). Ph chromosome continued to exist in CR patients with complete remission, and Ph chromosome disappeared after complete remission in Ph + ALL patients. There was no significant difference between the two groups in age, sex, and the number of naive naive cells in bone marrow (P> 0.05). Conclusions Ph + ALL has different clinical features and response to treatment of acute myeloid leukemia.