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目的比较三种蒽环类抗癌药治疗非何杰金淋巴瘤的近期疗效和毒性反应。方法用BACOP和CHOP方案治疗非何杰金淋巴瘤共145例。BACOP方案用法为ADM25mg／m2或THP25mg／m2或EPI30mg／m2，iv，d1、8；CTX650mg／m2，iv，d1、8；VCR1．4mg／m2．iv，d1、8；PYM8mg，im，d1、3、8、10；PDN40mg／m2，po，d1—14，28d为1周期。CHOP方案为ADM40mg／m2或THP45mg／m2或EPI50mg／m2，iv，d1；CTX750mg／m2，iv．d1；VCR1．4mg／m2,iv．d1；PDN60mg／m2．po，d1—5，21d为1周期。结果ADM．THP．EPI组CR率分别为37．1％、41．3％、48．6％．CR＋PR率分别为71．0％、80．4％、83．8％，P＞0．05，ADM组心脏毒性和胃肠道反应明显高于THP组和EPI组，P＜0．05，THP组和EPI组近期疗效和毒性反应相似，但THP价格和用量均低于EPI。结论THP可替代EPI治疗非何杰金淋巴瘤．尤其适用于老年患者。
Objective To compare the short-term efficacy and toxicity of three anthracycline anticancer drugs for non-Hodgkin’s lymphoma. Methods A total of 145 patients with non-Hodgkin’s lymphoma were treated with BACOP and CHOP. The BACOP regimen used ADM 25 mg/m2 or THP 25 mg/m2 or EPI 30 mg/m2, iv, d1, 8; CTX 650 mg/m2, iv, d1, 8; VCR 1.4 mg/m2. Iv, d1, 8; PYM8mg, im, d1, 3, 8, 10; PDN40mg/m2, po, d1-14, 28d is 1 cycle. The CHOP protocol is ADM 40 mg/m2 or THP 45 mg/m2 or EPI 50 mg/m2,iv,d1; CTX 750 mg/m2,iv. D1; VCR 1.4 mg/m2, iv. D1; PDN60mg/m2. Po, d1 - 5, 21d is 1 cycle. The result ADM. THP. The EPI group CR rate was 37.1%, 41.3%, and 48.6%, respectively. The CR+PR rates were 71.0%, 80.4%, and 83.8%, respectively, P>0.05. Cardiac toxicity and gastrointestinal reactions in the ADM group were significantly higher than those in the THP and EPI groups, P<0.05, THP. The short-term efficacy and toxicity of the group and EPI group were similar, but the THP price and dose were lower than the EPI. 2. Conclusion THP can replace EPI in the treatment of non - Hodgkin ’s lymphoma. Especially suitable for elderly patients.