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Nisoldipine 10μg/kg明显缩小家兔心肌梗塞范围,3μg/kg明显降低麻醉狗血压及左室内压,减慢心率,增加冠脉血流量及冠状窦血氧含量;1,3,10μg/kg降低麻醉狗冠脉及椎动脉阻力强于股动脉阻力。1～10μg明显增加离体豚鼠心脏冠脉沉量,抑制心肌收缩振幅,大剂量则减慢心率。2.6×10~(-10)～1×10~(-8)M非竞争性对抗KCl收缩家兔离体主动脉条反应,但不影响去甲肾上腺素所致收缩反应。nisoldipine抑制Cacl_2所致离体兔耳血管收缩反应的IC_(50)为1.7×10~(-11)M,而抑制去甲肾上腺素收缩反应的JC_(50)为4.0×10~(-4)M。小鼠灌胃LD_(50)为292±32mg/kg。
Nisoldipine 10μg/kg significantly reduced the myocardial infarction range in rabbits, 3μg/kg significantly reduced blood pressure and left ventricular pressure in anesthetized dogs, slowed heart rate, increased coronary blood flow and coronary sinus oxygen content; 1,3,10μg/kg reduced anesthesia Dog coronary artery and vertebral artery resistance is stronger than femoral artery resistance. 1 ~ 10μg significantly increased the coronary vasodilation in isolated guinea pig heart, inhibited myocardial contraction amplitude, high doses slowed the heart rate. 2.6×10~(-10)–1×10~(-8)M non-competitively antagonized the response of KCl-contracted aortic strips in rabbits, but did not affect the contractile response induced by norepinephrine. The IC_(50) of nisoldipine inhibited the vasoconstriction response of isolated rabbit ear induced by Cacl_2 was 1.7×10~(-11)M, while the JC_(50) inhibiting norepinephrine contraction was 4.0×10~(-4). M. LD_(50) was 292±32mg/kg in mice.