自发现白细胞介素-6(IL-6)是多发性骨髓瘤的生长因子以后,大量的研究力图进一步论证IL-6在调控肿瘤细胞生存及增殖、肿瘤性生长因子的信号传导、及其与肿瘤的相关性,进而探索新的治疗手段和途径.本文就近来有关这方面的进展结合自己参与的工作作一简述:1 IL-6及其受体的生物学特性和调节 Since the discovery of interleukin-6 (IL-6) as a growth factor of multiple myeloma, a large number of studies have sought to further demonstrate that IL-6 regulates tumor cell survival and proliferation, tumor growth factor signaling, and their The relevance of tumors and the exploration of new treatments and approaches. This article gives a brief description of the recent progress in this area combined with the work they are involved in: 1 The biological characteristics and regulation of IL-6 and its receptors