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目的了解吸毒人群中丙型肝炎病毒(HCV)感染状况及其影响因素。方法采集广州市海珠区美沙酮门诊吸毒人员血标本用酶联免疫吸附试验(ELl SA)法检测血清中抗-HCV,同时采用问卷调查收集吸毒人员相关资料并分析。结果美沙酮维持治疗门诊492例吸毒人员抗-HCV总感染率为87.40%;未婚或离婚或丧偶者抗-HCV阳性率高于已婚者(χ2=4.55,P<0.05);吸毒人员中HCV的感染与吸毒方式、时间年限有关;静脉吸毒HCV感染率显著高于非静脉吸毒者(χ2=23.91,P<0.01),吸毒年限越长,HCV感染率越高(χ2=107.60,P<0.01);不同年度、不同年龄及不同性别抗-HCV阳性率差异均无统计学意义(χ2=0.06~3.67,均P>0.05)。结论静脉注射吸毒是吸毒人员HCV感染的高危人群,HCV感染的影响因素与吸毒方式、吸毒年限有关。
Objective To understand the status of hepatitis C virus (HCV) infection among drug users and its influencing factors. Methods Blood samples from methadone clinics of Haizhu District of Guangzhou were collected for the detection of anti-HCV in serum by ELISA, and the related data of drug addicts were collected and analyzed by questionnaire. Results The total anti-HCV infection rate was 87.40% among 492 drug addicts in methadone maintenance treatment clinics. The positive rate of anti-HCV in unmarried or divorced or widowed persons was higher than that in married persons (χ2 = 4.55, P <0.05) The infection rate of HCV was significantly higher than that of non-intravenous drug users (χ2 = 23.91, P <0.01). The longer the drug use duration was, the higher the HCV infection rate was (χ2 = 107.60, P <0.01) There was no significant difference in the positive rates of anti-HCV among different years, ages and sex (χ2 = 0.06-3.67, all P> 0.05). Conclusion Intravenous drug abuse is a high risk group of HCV infection in drug addicts. The influencing factors of HCV infection are related to the mode of drug use and the duration of drug abuse.