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目的:对艾滋病(AIDS)并发真菌性脑膜炎的流行病学、临床特点、诊断及治疗进行总结和分析。方法:报告2例AIDS并发真菌性脑膜炎的临床资料,并结合国内、外相关文献分析。结果:2例男性,主要表现头痛、发热、抽搐。脑脊液真菌培养1例为罗伦隐球菌,另1例为新型隐球菌。均予治疗,前者因脑疝住院期间死亡,后者病情稳定仍在随访中。HIV-1抗体均为阳性。结论:真菌性脑膜炎是AIDS患者常见的机会性感染,为AIDS的主要致死病因之一,需及时诊断治疗。
Objective: To summarize and analyze the epidemiology, clinical features, diagnosis and treatment of AIDS complicated with fungal meningitis. Methods: The clinical data of two cases of AIDS complicated with fungal meningitis were reported and analyzed with relevant literature at home and abroad. Results: Two men, mainly headache, fever, convulsions. One case of cerebrospinal fluid fungus was Cryptococcus neoformans and the other was Cryptococcus neoformans. All were treated, the former died of herniation during hospitalization, the latter is still stable in the follow-up. HIV-1 antibodies are positive. Conclusions: Fungal meningitis is a common opportunistic infection in AIDS patients. It is one of the major causes of AIDS and needs timely diagnosis and treatment.