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合成本品可由三种相似的方法合成得到。 1)N-乙酰基-L-甲硫丁氨酸(Ⅰ)与氯甲巴胺酸乙酯(Ⅱ)和三乙胺在氯仿中反应得到其相应的酸酐(Ⅲ),Ⅲ再于氯仿中在三乙胺存在下与3,4-双-(乙酯氧基)苯乙胺-甲苯磺酸盐(Ⅳ)缩合。 2)Ⅰ和N-羟基环丁二酰胺(Ⅴ)在二氧杂环己烷中用双环己基碳化二亚胺(DCC)-
Synthesis of this product can be synthesized by three similar methods. 1) Reaction of N-acetyl-L-methionine (I) with ethyl chlorometalate (II) and triethylamine in chloroform to give the corresponding anhydride (III) and then in chloroform With 3,4-bis- (ethyl ester oxy) phenethylamine-tosylate (IV) in the presence of triethylamine. 2) I and N-hydroxycyclobutylaminamide (V) were dicyclohexylcarbodiimide (DCC) -