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检测52例大肠癌病人的空腹血清胃泌素,并分析与病理类型、临床分期及手术的关系。结果大肠癌病人的空腹血清胃泌素水平(110.3±98.2 Pg/ml)显著高于对照组(72.8±23.4 Pg/ml);分化良好腺癌病人(122.4±82.0Pg/ml)显著高于低分化腺癌病人(75.0±14.6Pg/ml);Ⅰ、Ⅱ期者(125.6±102.2Pg/ml)显著高于Ⅲ、Ⅳ者(82.7±22.5 Pg/ml);根治术后(94.2±21.2 Pg/ml)较术前(119.2±92.4 Pg/ml)显著降低;而姑息手术后(68.2±15.3 Pg/ml)较术前(74.2±15.5 Pg/ml)无显著变化。结果表明胃泌素测定有助于大肠癌的诊断、治疗和预后的判别。
Detected fasting serum gastrin in 52 patients with colorectal cancer and analyzed the relationship with pathological type, clinical stage and surgery. Results Fasting serum gastrin levels in patients with colorectal cancer (110.3±98.2 Pg/ml) were significantly higher than those in the control group (72.8±23.4 Pg/ml); patients with well-differentiated adenocarcinoma (122.4±82.0 Pg/ml) were significantly higher than those in the control group. Patients with differentiated adenocarcinoma (75.0±14.6 Pg/ml); patients with stage I and II (125.6±102.2 Pg/ml) were significantly higher than those of patients with III and IV (82.7±22.5 Pg/ml); after radical surgery (94.2±21.2 Pg) Compared with preoperative (119.2±92.4 Pg/ml), it was significantly lower than that of postoperative (68.2±15.3 Pg/ml) and preoperative (74.2±15.5 Pg/ml). The results show that gastrin determination is helpful for the diagnosis, treatment and prognosis of colorectal cancer.