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甲氧氟烷麻醉后所发生的多尿性肾功能不全系由其体内分解产物无机氟所致。但是,在最近开发的或正在开发的吸入麻醉药中,几乎所有乙醚型碳氢化合物中的氢巳被卤素(以氟原子为主)所置换。一分子甲氧氟烷中有二个氟原子,而在新的吸入麻醉药中则含有更多的氟原子。因此在这些新的吸入麻醉药中,由其体内分解产物无机氟引起肾毒性的可能性是令人担心的。
Methoxyflurane anesthesia occurs after polyuria renal insufficiency due to its in vivo decomposition products caused by inorganic fluoride. However, in the case of inhaled anesthetics that have been recently developed or under development, almost all of the hydrogens in ether-based hydrocarbons have been replaced by halogens, predominantly fluorine atoms. There are two fluorine atoms in one molecule of methoxyhalogen, and more fluorine atoms in new inhalation anesthetics. Therefore, among these new inhaled anesthetics, the possibility of nephrotoxicity caused by inorganic fluoride, which is the product of its in vivo decomposition, is cause for concern.