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目的测定丙泊酚靶控输注(TCI)时瑞芬太尼用于小儿无肌松气管插管的半数有效效应室浓度(EC50)。方法 (6.6±1.0)岁ASAⅠ级择期行整形外科手术患儿28例,丙泊酚以效应室靶浓度6μg/ml输注,血浆和效应室浓度达平衡后开始TCI瑞芬太尼,在瑞芬太尼血浆和效应室浓度达平衡后气管插管。瑞芬太尼效应室靶浓度按Dixon序贯法法则确定,起始浓度为4.0 ng/ml,相邻效应室靶浓度梯度为0.2 ng/ml。结果瑞芬太尼用于小儿无肌松气管插管的EC50为4.67ng/ml,95%可信区间为4.52~4.87 ng/ml。结论在复合丙泊酚效应室靶浓度6μg/ml输注条件下,瑞芬太尼用于小儿无肌松气管插管的EC50为4.67 ng/ml,95%可信区间4.52~4.87 ng/ml。
Objective To determine the median effective concentration (EC50) of remifentanil for intubation in children with muscle-free bronchial intubation during target-controlled infusion of propofol (TCI). Methods Twenty-eight ASA grade Ⅰ children undergoing orthopedic surgery (6.6 ± 1.0) were enrolled in this study. Propofol was infused at a concentration of 6 μg / ml in the effector chamber. TCI remifentanil was started after the plasma and effector cell concentrations were at equilibrium. Endotracheal intubation after equilibration of fentanyl plasma and effect chamber. The remifentanil effect chamber target concentration was determined by the Dixon Sequential Method with a starting concentration of 4.0 ng / ml and a target concentration gradient of 0.2 ng / ml in the adjacent effector cells. Results The EC50 of remifentanil for pedicless muscle-tracheal intubation was 4.67ng / ml, with a 95% confidence interval of 4.52 ~ 4.87 ng / ml. Conclusions The EC50 of remifentanil for muscle-free intubation in children is 4.67 ng / ml and the 95% confidence interval is 4.52 ~ 4.87 ng / ml .