关于氨基甙类抗生素对内耳和肾脏的毒性问题多年来一直在研究和争论。有人认为其毒性与其在血中的最大浓度有关,因此不宜静脉注射;也有人认为在下一次给药之前的血中最低浓度比血中的最大浓度更具有危险性;尚有其毒性与其在血中的浓度无关之说者。作者们通过给兔静脉内和肌肉内注射氨基甙类抗生素,对比了这两组动物注射后血清和外淋巴液中的药物浓度,并对 The toxicity of aminoglycosides to the inner ear and the kidneys has been studied and debated over the years. Some people think its toxicity and its maximum concentration in the blood, it is not suitable for intravenous injection; some people think that before the next dose of blood in the blood concentration of the lowest concentration than the maximum concentration of blood more dangerous; there are its toxicity and its in the blood The concentration of unrelated person. By injecting aminoglycosides intravenously and intramuscularly in rabbits, the authors compared drug concentrations in both serum and perilymph after injection of these two animals, and compared