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目的分析非糖尿病人群中腰臀比与慢性肾脏病的相关性,比较其在男性和女性中的差异。方法选择2012年6月~10月我国南方社区居民进行横断面筛查(n=2142),排除糖尿病人群。将参与者分为男性组和女性组,并以腰臀比四分位数将男女各分为4组。采用Logistic回归模型分析在非糖尿病人群中腰臀比与慢性肾脏病的相关性,并比较其在男性和女性中的差异。结果在女性非校正模型中,腰臀比与慢性肾脏病显著相关(OR 7.29,95%CI 3.56 to 16.32,P<0.001)。在校正潜在混杂因素如年龄、高血压史、冠心病史、吸烟饮酒史、收缩压、舒张压、甘油三酯、高密度脂蛋白后,二者仍相关(OR 6.13,95%CI 2.56 to 15.20,P=0.003)。在男性非校正模型中,腰臀比四分位数最高与最低组慢性肾脏病与腰臀比的OR值为2.44(95%CI,0.98 to 4.97,P=0.103)。结论在非糖尿病人群中,女性腰臀比是慢性肾脏病独立危险因素,在男性中无相关性。
Objective To analyze the relationship between waist-to-hip ratio and chronic kidney disease in non-diabetic population and to compare the difference between male and female. Methods From June to October 2012, community residents from southern China conducted cross-sectional screening (n = 2142) to exclude diabetic patients. Participants were divided into male and female groups, and men and women were divided into 4 groups with a waist-hip ratio quartile. Logistic regression model was used to analyze the relationship between waist-to-hip ratio and chronic kidney disease in non-diabetic population and to compare the difference between male and female. Results In the female non-adjusted model, waist-hip ratio was significantly associated with chronic kidney disease (OR 7.29, 95% CI 3.56 to 16.32, P <0.001). Correlation of potential confounders such as age, history of hypertension, history of coronary heart disease, history of smoking and drinking, systolic blood pressure, diastolic blood pressure, triglycerides, and high-density lipoprotein remained associated (OR 6.13, 95% CI 2.56 to 15.20 , P = 0.003). In the male non-corrected model, OR was 2.44 (95% CI, 0.98 to 4.97, P = 0.103) for the patients with the highest and lowest WHR and WHR. Conclusion In non-diabetic population, waist-hip ratio of women is an independent risk factor of chronic kidney disease and no correlation in males.