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雷公藤(Tripterygium Wilfordii Hook.f.)作为药物最早收载于《神农本草经》用于治疗关节炎,跌打损伤,皮肤病等。近20年来。国内外科学家研究发现抗炎,抗肿瘤,抗生育及免疫调节作用,临床用于治疗风湿性关节炎及多种自身免疫性疾病疗效极佳。据文献报导已从雷公藤中分得倍半萜,二萜,三萜及生物碱等化合物190多个。近年来我们对雷公藤植物采用不同方法,不同部位进行较系统的研究。本文先介绍从雷公藤根皮乙醇提取物中分得的二萜及其它成分。
Tripterygium Wilfordii Hook.f. was first collected in “Shen Nong Ben Cao Jing” for the treatment of arthritis, bruises, skin diseases and the like. In the past 20 years. Domestic and foreign scientists found that anti-inflammatory, anti-tumor, anti-fertility and immune regulatory role, the clinical treatment of rheumatoid arthritis and a variety of autoimmune diseases excellent efficacy. It has been reported in the literature from Tripterygium divided sesquiterpene, diterpene, triterpenes and alkaloids and other compounds more than 190. In recent years, we used different methods to plant Tripterygium wilfordii and conducted systematic research on different parts. This article first introduces the diterpenoids and other components that are derived from the ethanolic extract of the root bark of Tripterygium wilfordii.