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目的探讨新疆和田墨玉县维吾尔族农村女性人乳头状瘤病毒(human papilloma virus,HPV)感染现状及感染相关因素,为新疆地区子宫颈癌防治提供科学依据和指导。方法 2013年5月15日-11月15日在和田墨玉县选取墨玉镇、喀尔赛乡、奎雅乡、扎瓦乡、雅瓦乡的21~60岁维吾尔族有性生活女性6 000例,采用整群抽样的方法进行HPV检测及HPV感染相关因素的问卷调查,问卷内容包括基本信息、婚育状况、性行为等。由2名妇科医生采集标本并应用care HPV检测,以结果阳性判定为HPV感染,对数据进行统计学分析。结果共输入有效问卷6 000份,研究人群HPV总感染率为8.4%。HPV感染与年龄(χ2=15.835,P<0.001)、婚姻状况(χ2=12.805,P<0.001)、职业(χ2=15.540,P<0.001)、文化程度(χ2=25.224,P<0.001)、家庭收入(χ2=5.637,P<0.05)有关。多因素Logistic回归分析显示:文化程度、同房频次与HPV感染存在关联(P<0.05)。结论新疆和田地区墨玉县维吾尔族农村妇女的HPV感染与年龄、婚姻状况、职业、同房频次存在一定关联。应该针对相关高危因素制定相应措施,规范人群行为,加强45岁以上妇女的筛查,进行有效干预。
Objective To investigate the current status of infection of human papilloma virus (HPV) in rural Uyghur rural women in Moyu County, Hetian of Xinjiang and to provide a scientific basis and guidance for the prevention and treatment of cervical cancer in Xinjiang. Methods From May 15 to November 15, 2013, Uyghur women of 21 to 60 years of age living in Moyu Township, Karsai Township, Quya Township, Zhawa Township and Yawa Township were selected from Moyu County, Hetian County. 6 000 cases, using cluster sampling method for HPV testing and HPV infection related to the questionnaire survey, the questionnaire includes basic information, status of marriage and childbirth, sexual behavior and so on. Two gynecologists collected specimens and applied the care HPV test, the results were positive for HPV infection, the data were statistically analyzed. Results A total of 6 000 valid questionnaires were entered. The total HPV infection rate in study population was 8.4%. The correlation between HPV infection and age (χ2 = 15.835, P <0.001), marital status (χ2 = 12.805, P <0.001) Income (χ2 = 5.637, P <0.05). Multivariate Logistic regression analysis showed that there was a correlation between educational level, frequency of intercourse and HPV infection (P <0.05). Conclusion HPV infection in rural Uyghur women in Moyu County of Hetian Region is related to age, marital status, occupation and frequency of intercourse. Corresponding risk factors should be developed for appropriate measures to regulate the behavior of the population, strengthen screening of women over the age of 45, for effective intervention.