药物超敏反应综合征(drug-induced hypersensitivity syndrom,DIHS)是一种临床较为少见的严重药物不良反应。DIHS主要由别嘌醇、卡马西平、苯妥英钠等少数药物引起,曾有布洛芬引起DIHS的报道,而由布洛芬混悬液所致患者尚未发现有文献报道。布洛芬混悬液的不良反应有过敏性休克、消化道出血、粒细胞减少症、高热惊厥等。笔者收治了1例由布洛芬混悬液所致的DIHS,现报告如下。 Drug-induced hypersensitivity syndrom (DIHS) is a clinically rare serious adverse drug reaction. DIHS is mainly caused by allopurinol, carbamazepine, phenytoin and a few other drugs. There were reports of ibuprofen-induced DIHS. However, no reports of ibuprofen suspension have been found in the literature. Adverse reactions of ibuprofen suspension include anaphylactic shock, gastrointestinal bleeding, neutropenia, febrile seizures and so on. I admitted to a case of ibuprofen suspension caused by DIHS, are as follows.