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本文对复方感冒宁片中扑热息痛和扑尔敏的含量测定方法进行了研究。具休方法为将试样分别经乙醇及氯仿提取,然后用薄层层析。以氯仿:甲醇:氢氧化氨(10∶1∶0.5),(10∶1∶0.2)展开,可以将扑热息痛、扑尔敏同其他杂质分离。用碘蒸气显色,记下斑点位置,挥尽碘,刮取斑点,分别用甲醇和N/2硫酸洗脱,用紫外吸收法测定含量。本法效果较好,适用于实际生产。
In this paper, the method of determination of acetaminophen and chlorpheniramine in compound ganmao tablets was studied. The rest method is to separate the samples with ethanol and chloroform, and then use thin layer chromatography. Chloroform:methanol:ammonium hydroxide (10:1:0.5), (10:1:0.2) can be used to separate paracetamol and chlorpheniramine from other impurities. The color was developed with iodine vapor, the spots were recorded, the iodine was splashed off, the spots were scraped off, eluted with methanol and N/2 sulfuric acid, respectively, and the content was determined by ultraviolet absorption method. This method is effective and suitable for practical production.