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由于近年来结核病发病率的上升,结核性脑膜炎(以下简称结脑)发病人数也有明显增多。强化抗结核方案中能有效透过脑膜的药物较少,脑脊液中浓度偏低,而且结核耐药菌株感染增多,使结脑的疗效受到严重影响,因而成为结核病中死亡率最高的一种类型。据近20年的国内文献报道结脑死亡率为15％左右。第Ⅲ代氟喹诺酮类抗生素(培福新属此类)对革兰氏阴性杆菌及结核分枝杆菌(包括耐药菌株)有明显的杀菌、抑菌作用,而且有组织渗透性强,脑
Due to the rising incidence of tuberculosis in recent years, the incidence of tuberculous meningitis (hereinafter referred to as tuberculous) also increased significantly. In the intensive anti-tuberculosis program, there are fewer drugs that can effectively penetrate the meninges, the concentration in cerebrospinal fluid is low, and the infection with tuberculosis drug-resistant strains is increased, so that the curative effect of tuberculin is severely affected, thus becoming the type with the highest mortality rate in tuberculosis. According to nearly 20 years of domestic literature, tuberculosis death rate is about 15%. The third generation of fluoroquinolone antibiotics (Pegasys such new genus) Gram-negative bacilli and Mycobacterium tuberculosis (including drug-resistant strains) have obvious bactericidal and bacteriostatic effects, but also has strong tissue permeability, brain