中毒性休克综合征(toxic shocksyndrome.TSS)是近年来才被逐渐认识和引起关注的一组临床综合征。1978年Todd 等(?)首先报道了7例患者(年龄8～17岁)以发热、弥漫性红皮症、结合膜充血、皮下水肿、昏厥、低血压或休克、恶心、呕吐、水样腹泻及多脏器功能障碍为特征的综合征。血培养阴性,但从患者鼻咽部、阴道、气管粘膜和化脓性灶中能分离出金黄色葡菌(以下简称金葡菌)被认为是由金葡菌毒素引起的多脏器功能障碍、休克的一种急性中毒性疾病,命名为中毒性休克综合征。本文就近年对该综合征的研究作一综述。病因金葡菌局部寄生或感染产生的毒素,被认为是引起TSS 的病因。TSS 患者的咽部、宫颈。阴道和直肠等处金葡菌分离率很高,尤以阴道为甚。美国疾病控制中心报告一组44例女性TSS 患者中43例(98%) Toxic shock syndrome (TSS) is a group of clinical syndromes that have been gradually recognized and attracted attention in recent years. In 1978, Todd et al. (?) First reported seven patients (aged 8-17 years) with fever, diffuse erythroderma, conjunctival congestion, subcutaneous edema, fainting, hypotension or shock, nausea, vomiting, watery diarrhea And multiple organ dysfunction syndrome. Blood culture negative, but from the patient’s nasopharynx, vagina, tracheal mucosa and purulent lesions can be isolated from Staphylococcus aureus (hereinafter referred to as Staphylococcus aureus) is considered to be caused by Staphylococcus aureus multiorgan dysfunction, Acute acute toxicosis of shock, named toxic shock syndrome. This article in recent years to make a review of the study of the syndrome. Cause of Staphylococcus aureus local parasites or infections toxins, is considered to cause the cause of TSS. TSS patients throat, cervix. Staphylococcus aureus isolation rate is high, especially in the vagina and rectum, especially in the vagina. The U.S. Centers for Disease Control reported 43 (98%) of 44 women with TSS,