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以甲基丙烯酸为功能单体,环丙沙星为模板分子,采用悬浮聚合的方法制备了球形分子印迹聚合物,并用扫描电镜对聚合物进行了表征;通过平衡吸附法研究了聚合物对模板分子及其类似物的吸附行为和选择识别能力.结果表明,实验所研究的分子印迹聚合物,吸附4 h后基本接近最大吸附量,其中模板分子、MMA和交联剂物质的量比为1∶6∶20的MIPMs2最大表观吸附量为183.18μmol/g,印迹因子为1.58,效果最佳.吸附过程存在两类结合位点,一类为特异性印迹吸附,另一类为非特异性吸附;该分子印迹聚合物有很好的选择吸附性和再生性,可用于环丙沙星药物的分析和分离.
Using methacrylic acid as the functional monomer and ciprofloxacin as the template molecule, spherical molecularly imprinted polymers were prepared by suspension polymerization. The polymers were characterized by scanning electron microscopy. The effects of the polymer on the template The results showed that the molecularly imprinted polymers studied in the experiment were close to the maximum adsorption capacity after adsorption for 4 h, in which the molar ratio of template molecule, MMA and crosslinking agent was 1 : 6:20 MIPMs2 maximum apparent adsorption capacity of 183.18μmol / g, imprinting factor of 1.58, the best results. There are two types of binding sites adsorption process, one for the specific blotting adsorption and the other for non-specific adsorption The molecularly imprinted polymer has a good choice of adsorbability and reproducibility and can be used for the analysis and separation of ciprofloxacin drugs.