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通过分子表面的计算考察了三类金属硫蛋白 (大鼠金属硫蛋白亚型II,兔肝金属硫蛋白亚型I和II)二聚体和三聚体中组成单元之间的疏水性相互作用。计算结果表明二聚体和三聚体中各组成单元之间均可以形成较好的几何匹配。对于二聚体而言 ,单体和单体之间存在一定的疏水性相互作用 ,但作用力不强。在三聚体中 ,单体和二聚体之间的疏水残基能通过好的空间匹配形成很强的疏水性相互作用。对于这三种金属硫蛋白 ,二聚体中单体和单体之间的疏水性相互作用不存在明显差别 ,但对于三聚体中单体和二聚体之间的疏水性相互作用 ,大鼠金属硫蛋白亚型II和兔肝金属硫蛋白亚型II要明显强于兔肝金属硫蛋白亚型I。
The hydrophobic interaction between the constituent units of the three types of metallothioneins (rat metallothionein subtype II, rabbit hepta metallothionein subtype I and II) dimer and trimer was examined by molecular surface calculations . The calculated results show that the geometrical match between each unit of dimer and trimer can be achieved. For dimers, there is a certain hydrophobic interaction between monomer and monomer, but the force is not strong. In trimers, hydrophobic residues between monomers and dimers can form strong hydrophobic interactions through good spatial matching. For the three metallothioneins, there is no significant difference in the hydrophobic interaction between monomers and monomers in the dimer, but for the hydrophobic interaction between monomers and dimers in the trimer, large Murine metallothionein subtype II and rabbit liver metallothionein subtype II were significantly stronger than rabbit liver metallothionein subtype I.