肿瘤的淋巴道转移是影响患者预后的重要因素之一。由于近年来淋巴管内皮细胞特异性标志物的发现,对淋巴管生成的机制和肿瘤的淋巴转移的研究得到深入。血管内皮生长因子D是近年来发现的淋巴管生成因子之一。研究表明,血管内皮生长因子D可促进肿瘤淋巴管生成和淋巴道转移,抗新生淋巴管治疗有望成为肿瘤生物治疗新模式。 Tumor lymph node metastasis is an important factor affecting the prognosis of patients. Due to the discovery of endothelial cell-specific markers of lymphatic vessels in recent years, the mechanisms of lymphangiogenesis and lymphatic metastasis of tumors have been further studied. Vascular endothelial growth factor D is one of the lymphangiogenesis factors found in recent years. Studies have shown that vascular endothelial growth factor D can promote tumor lymphangiogenesis and lymphatic metastasis, anti-lymphangiogenesis is expected to become a new model of tumor biological treatment.