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对具有高MSAFP值病人的产前监护标准,包括胎儿超声波评价、羊膜穿刺以测羊水AFP值。但羊水细胞染色体的分析,一直未作为对这种病人进行产前诊断的必要组成部分。本文报告2例在常规产前检查监护中发现有非常高的MSAFP值,而羊水AFP浓度正常。胎儿细胞染色体分析对其诊断至为重要。这2例均证实为胎儿三倍性染色体。病例1 24岁,白人,0-0-2-0,孕18周时MSAFP高达724ng/ml(16.5MoM),一周后复查结果是537.2ng/ml(19.9MoM)。病人有慢性哮喘及甲状腺功能低下史,曾用过Theophylline
Prenatal care criteria for patients with high MSAFP values include fetal ultrasound evaluation and amniocentesis for amniotic fluid AFP values. However, analysis of amniotic fluid cell chromosomes has not been used as an essential part of prenatal diagnosis of this patient. This article reports two cases found in the routine custody of prenatal care has a very high MSAFP value, while amniotic fluid AFP concentration. Fetal cell chromosome analysis is crucial for its diagnosis. These two cases were confirmed as triad of the fetus chromosomes. Case 1 24-year-old, white, 0-0-2-0, MSAFP up to 724 ng / ml (16.5 MoM) at 18 weeks of gestation and 537.2 ng / ml (19.9 MoM) after 1 week of review. Patients with chronic asthma and hypothyroidism history, had used Theophylline