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目的探讨肾肿瘤患者围术期血清皮质醇和细胞因子IL-2、IL-6、IL-8的变化,并对2种不同的手术方式进行对比观察。方法60例需行肾肿瘤切除的患者,按不同的手术方式分为2组:即LO组(腹腔镜组)和AO(开腹手术组)。检测患者围手术期血清皮质醇和细胞因子IL-2、IL-6、IL-8的水平。结果术前2组患者血清皮质醇和细胞因子含量无显著性差异(P>0.05),术后8小时、24小时、48小时、72小时2组患者血清皮质醇和细胞因子较术前明显升高(P<0.05),且开腹手术组明显高于腹腔镜组(P<0.01)。结论腹腔镜外科技术能有效地降低围手术期应激反应,减轻创伤。
Objective To investigate the changes of perioperative serum cortisol and IL-2, IL-6 and IL-8 levels in patients with renal cell carcinoma and to compare the two different surgical methods. Methods Sixty patients undergoing resection of renal tumors were divided into two groups according to different surgical methods: LO group (laparoscopic group) and AO (open group). Perioperative serum cortisol and cytokines IL-2, IL-6, IL-8 levels were measured. Results There was no significant difference in serum cortisol and cytokines levels between the two groups before operation (P> 0.05). Serum cortisol and cytokines in the two groups at 8, 24, 48 and 72 hours after operation were significantly higher than those before operation P <0.05), and laparoscopic surgery group was significantly higher (P <0.01). Conclusion Laparoscopic surgery can effectively reduce perioperative stress response and reduce trauma.