AIM:TO study the effect of environmental hyperthermiaon gastrin,somatostatin and motilin in rat ulcerated antralmucosa.METHODS:Forty-two Wistar rats were equally divided intosix groups,according to the room temperature(high andnormal)and the treatment(acetic acid,normal saline andno treatment).Levels of gastrin,somatostatin and motilinin rat ulcerated antral mucosa were measured with aradioimmunoassay method.RESULTS:The average temperature and humidity were32.5℃ and 66.7% for the high temperature group,and21.1℃ and 49.3% for the normal temperature group,respectively.Gastric ulcer model was successfully inducedin rat injected with 0.05 mL acetic acid into the antrum.Inrats with gastric ulcers,the levels of gastrin and motilinincreased,whereas the somatostatin level declined in antralmucosa,compared with those in rats treated with normalsaline and the controls.However,the change extent in thelevels of gastrin,motilin and somatostatin in antral mucosawas less in the high temperature group than in the normaltemperature group.CONCLUSION:The levels of gastrin,somatostatin andmotilin in rat ulcerated antral mucosal tissue remain relativelystable in a high temperature environment,which may relateto the equilibration of the dynamic system. AIM: TO study the effect of environmental hyperthermia on gastrin, somatostatin and motilin in rat ulcerated antral mucosa. METHODS: Forty-two Wistar rats were equally divided intosix groups, according to the room temperature (high and normal) and the treatment (acetic acid, normal saline and no treatment). Levels of gastrin, somatostatin and motilinin rat ulcerated antral mucosa were measured with aradioimmunoassay method .RESULTS: The average temperature and humidity were 32.5 ° C and 66.7% for the high temperature group, and 21.1 ° C and 49.3% for the normal temperature group, respectively. Genetic ulcer model was successfully induced in rat injected with 0.05 mL of acetic acid into the antrum. Invasive with gastric ulcers, the levels of gastrin and motilin increased, and the somatostatin level declined in antral mucosa, compared with those in rats treated with Normalsaline and the controls. Yet, the change extent in the levels of gastrin, motilin and somatostatin in antral mucosawas less in the high temperature g roup than in the normal temperature group. CONCLUSION: The levels of gastrin, somatostatin and motilin in rat ulcerated antral mucosal tissue remain relatively stable in a high temperature environment, which may relate to the equilibration of the dynamic system.