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1984年12月至1991年4月应用全身照射技术对16例白血病患者进行异体骨髓移植前的大剂量全身照射,均采用60钴γ射线,用自行设计和制作的蜡板根据射线均匀度不一制成剂量均整装置,并且采用6次交替仰卧和侧卧的全身照射,使剂量均匀度在人体最高和最低剂量点仅相差8.2%。剂量率1.65~5.4cGy/min,总剂量随剂量率的增加而递减,从900cGy降至660cGy。结果:放射反应轻,生长发育影响小,生存质量较高,1、2和3年生存率分别为81.3%(13/16)、75.0%(9/12)和62.5%(5/8)。无一例发生间质性肺炎,仅1例出现骨髓排斥和复发。建议适宜剂量率4~5cGy/min,总剂量700~800cGy。
From December 1984 to April 1991, whole-body irradiation with total body irradiation was performed on 16 patients with leukemia before allogeneic bone marrow transplantation. All of them were irradiated with 60-cobalt gamma rays. The self-designed and fabricated wax plates were not uniform according to the ray uniformity. A dose-shaping device was set up, and six alternating supine and lateral body irradiations were used to achieve a difference of 8.2% in the dose uniformity between the highest and lowest dose points in the human body. The dose rate was 1.65 to 5.4 cGy/min, and the total dose decreased with increasing dose rate, from 900cGy to 660cGy. Results: The radiation reaction was mild, the growth and development were little, and the quality of life was higher. The 1-, 2-, and 3-year survival rates were 81.3% (13/16), 75.0% (9/12), and 62.5%, respectively. (5/8). No interstitial pneumonia occurred, and only one case showed bone marrow rejection and recurrence. The recommended dose rate is 4 to 5 cGy/min, and the total dose is 700 to 800 cGy.