抗生素诱导革兰氏阴性菌(GNB)释放游离内毒素(FLPS),已在体外得到证实,并发现与抗生素的作用机制、作用时间及抗生素浓度有关。大部分体内外研究证实,部分抗生素可 诱导GNB释放FLPS,使机体某些细胞因子产生过多,加重炎症反应及病情,但其临床意义尚需进一步研究。本文就抗生素诱导GNB释放FLPS的机理及临床意义的有关研究近况作一综述。 Antibiotic-induced release of free endotoxin (FLPS) from Gram-negative bacteria (GNB) has been demonstrated in vitro and found to be related to the mechanism of action, duration of action and concentration of antibiotics. Most in vitro and in vivo studies confirm that some antibiotics can induce GNB to release FLPS, which can cause excessive production of certain cytokines and aggravate inflammatory reaction and disease. However, its clinical significance needs further study. This article reviews the current status of the mechanism and clinical significance of antibiotic-induced GNB release of FLPS.