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资料表明有十分之一的夫妇因不能生育而就诊,而其中有10%～30%是由于抗精子抗体(AsAb)引起,所以由AsAb导致的免疫性不育是一个重要的不育原因。最近有研究表明,硝苯地平在体外可以改变人精子膜功能完整性,成为导致不育的原因之一。本试验旨在研究AsAb对人精子膜功能完整性的影响,为临床正确诊断和治疗免疫性不育提供理论依据,同时为开发出更加安全有效的避孕药物提供有价值的信息。
The data show that one in ten couples who are unable to have children and 10% to 30% of them are due to anti-sperm antibodies (AsAb), so immunosuppression caused by AsAb is an important cause of infertility. Recent studies have shown that nifedipine in vitro can change the functional integrity of human sperm membrane, becoming one of the reasons leading to infertility. The aim of this study is to investigate the effect of AsAb on the functional integrity of human sperm membranes and to provide a theoretical basis for the correct diagnosis and treatment of immune infertility in clinical practice and to provide valuable information for the development of safer and more effective contraceptives.