论文部分内容阅读
耐药性癫是全球癫治疗的难题,目前有20%～30%的癫患儿为耐药性癫,可导致患儿心理行为、学习认知、社会交往障碍,严重影响患儿生活质量。耐药性癫发生机制复杂,尚未完全明确。耐药基因的表达、特殊的神经病理改变、特殊的癫综合征等指标有助于早期判断是否为耐药性癫。近年来,随着新型抗癫药物的应用、癫外科手术的开展、迷走神经刺激术及生酮饮食等治疗为耐药性癫患儿提供了治疗的希望。
Drug-resistant epilepsy is the global epilepsy treatment problems, there are currently 20% to 30% of children with epilepsy drug-resistant epilepsy, can lead to psychological behavior in children, cognitive learning, social barriers to social interaction, seriously affected Children’s quality of life. The mechanism of drug-resistant epilepsy is complex and not yet fully understood. Resistance gene expression, special neuropathological changes, special epilepsy syndrome and other indicators help early determine whether the drug-resistant epilepsy. In recent years, with the application of new anti-epileptic drugs, the development of epilepsy surgery, vagus nerve stimulation and ketogenic diet treatment for children with drug-resistant epilepsy provides the hope of treatment.