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目的了解云南省玉溪市人群麻疹免疫状况,为制定有效的控制消除麻疹措施提供科学依据。方法采取分层和整群抽样(PPS)法进行抽样调查,应用酶联免疫吸附试验法(ELISA间接法)检测人群麻疹抗体(MVIg G)含量(m IU/ml)。结果 2013-04-30/-06-30,全市辖区内共调查3 493人,麻疹抗体阳性率为97.62%,有保护率为87.72%,麻疹抗体几何平均浓度(Geometric Mean Concentration,GMC)为2 764.49毫国际单位(m IU/ml)。区县间人群MV-Ig G阳性率、GMC差异均有统计学意义(χ2=45.27,P<0.05,F=65.86,P<0.05);各年龄段人群MV-Ig G阳性率、GMC差异也有统计学意义(χ2=122.60,P<0.05,F=17.79,P<0.05),其中<17月龄人群抗体阳性率最低为90.21%,≥18岁年龄段人群麻疹GMC相对较低,仅为1902 m IU/ml;性别间人群MV-Ig G阳性率和GMC均无统计学意义(χ2=0.02,P>0.05,F=1.69,P>0.05)。结论玉溪市人群麻疹免疫效果较好,能有效控制麻疹的暴发流行。但距实现消除麻疹目标还存在一定的差距,尤其要加强<17月龄与>14岁人群的监测工作,根据监测结果适时调整麻疹疫苗免疫策略,最终实现控制乃至消除麻疹的目标。
Objective To understand the immune status of measles in population in Yuxi City, Yunnan Province, and to provide scientific evidence for the effective control of measles. Methods The stratified and cluster sampling (PPS) method was used to carry out sampling survey. The content of measles antibody (MVIg G) (m IU / ml) was detected by enzyme-linked immunosorbent assay (ELISA). Results 2013-04-30 / -06-30, a total of 3 493 people were investigated in the area of the city. The positive rate of measles antibody was 97.62%, the protective rate was 87.72%. Geometric Mean Concentration (GMC) of measles antibody was 2 764.49 milli International units (m IU / ml). The positive rate of MV-Ig G and the difference of GMC among the counties were statistically significant (χ2 = 45.27, P <0.05, F = 65.86, P <0.05) Statistical significance (χ2 = 122.60, P <0.05, F = 17.79, P <0.05), in which the lowest antibody positive rate was 90.21% in the age of <17 months, and the measles GMC in the age group of 18 years old was relatively low, only 1902 m IU / ml. The positive rates of MV-Ig G and GMC between the sexes were not statistically significant (χ2 = 0.02, P> 0.05, F = 1.69, P> 0.05). Conclusion The measles immunity in Yuxi City is better, which can effectively control the outbreak of measles. However, there is still a long way to go to achieve the goal of eliminating measles. In particular, we need to strengthen the monitoring of people aged <17 months and> 14 years and adjust the measles vaccine immunization strategy based on the monitoring results in order to eventually achieve the goal of controlling or even eliminating measles.