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目的：测定奈替米星体内ＰＡＥ，并探讨奈替米星ＡＵＣ与ＰＡＥ的相关性。 方法：用荧光偏振免疫分析仪检测病人血中奈替米星浓度并计算ＡＵＣ；以ＡＶＡＮＴＡＧ 全能自动化微生物分析仪，用光密度法测定病人血中奈替米星对９ 种受试菌的ＰＡＥ。 结果：奈替米星对耐药菌ＰＡＥ 很短甚至没有，对标准菌及临床分离敏感菌产生较长的ＰＡＥ，１２ ｈ 体内累加ＰＡＥ最大值达３６．８ ｈ，ＡＵＣ与累加ＰＡＥ相关良好。 结论：奈替米星对敏感菌可产生明显的体内ＰＡＥ，以ＡＵＣ值可以估算体内ＰＡＥ。
OBJECTIVE: To determine PAE in netilmicin and to investigate the correlation between netilmicin AUC and PAE. Methods: Fluorescence polarization immunoassay was used to detect the concentration of netilmicin in the blood of the patients and the AUC was calculated. The PAE of netilmycin in the blood of 9 kinds of tested bacteria was determined by optical density method with AVANTAG automated microbiological analyzer. Results: The netilmicin had no or short PAE, and had a long PAE to the standard bacteria and clinically isolated bacteria. The cumulative PAE up to 36.8 h after 12 h, and the correlation between AUC and cumulative PAE was good. CONCLUSION: Netilmicin can produce significant in vivo PAE on susceptible bacteria, and PAE in vivo can be estimated by AUC value.