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采用固体酸SO 2-4/Ti O2与金鸡纳碱奎尼丁[Quinidine(R)]进行负载,制备出具有较强氢键供体的SO 2-4/Ti O2/Quinidine(R)手性催化剂,并对比了金鸡纳碱奎尼丁及其衍生物金鸡纳碱奎尼丁-硫脲在不对称Mannich有机催化中的催化活性.实验结果显示:在相同的催化条件下,SO 2-4/Ti O2/quinidine(R)在不对称Mannich催化反应的催化活性性能高于金鸡纳碱奎尼丁,低于金鸡纳碱奎尼丁-硫脲.同时,通过催化条件优化,SO 2-4/Ti O2/quinidine(R)催化剂在间二甲苯为溶剂、-40℃及搅拌72 h的催化条件下,可获得具有较高光学活性的手性β-氨基酸酯类衍生物(89%~95%ee).
The SO 2-4 / Ti O2 / Quinidine (R) chiral ligands with strong hydrogen bond donor were prepared by loading solid SO 2-4 / Ti O 2 with quinidine (R) Catalyst and the catalytic activity of cinchona quinidine and its derivative cinchona quinidine-thiourea in asymmetric Mannich organic catalysis were compared.The experimental results show that under the same catalytic conditions, SO 2-4 / Ti O2 / quinidine (R) in asymmetric Mannich catalysis was higher than that of cinchona quinine, lower than that of cinchidin-thiourea.In the mean time, SO 2-4 / Ti O2 / quinidine (R) catalyst can obtain chiral β-amino acid ester derivatives with higher optical activity (89% -95%) under the catalysis conditions of m-xylene as solvent, % ee).