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目的了解晚期乳腺癌伴中性粒细胞缺乏(简称粒缺)患者抗菌药物应用情况,促进临床合理应用。方法采用回顾性分析方法,对郑州大学附属肿瘤医院2014年7月至2015年6月102例晚期乳腺癌伴粒缺患者抗菌药物使用的合理性进行分析。结果 102例晚期乳腺癌伴粒缺患者中发热率为27.4%;粒缺伴发热患者及粒缺不伴发热患者抗菌药物使用率分别为100%、39.2%;经验性应用抗菌药物品种选择、使用疗程及停药指征基本合理;存在的问题是,无指征预防性使用抗菌药物(28.4%),预防性应用抗菌药物品种选择不合理,经验性使用抗菌药物前标本送检率低(14.3%)。结论郑州大学附属肿瘤医院晚期乳腺癌伴粒缺患者抗菌药物使用基本合理,但仍存在部分不合理之处,需进一步改进。
Objective To understand the application of antimicrobial agents in patients with advanced breast cancer with neutrophilic granuloma (abbreviated as granulomagnetis) and to promote its clinical application. Methods The retrospective analysis method was used to analyze the rationality of antimicrobial agents use in 102 cases of advanced breast cancer patients with granulocyte-lesion from July 2014 to June 2015 in Cancer Hospital of Zhengzhou University. Results The incidence of fever in 102 cases of patients with advanced breast cancer with granuloma was 27.4%. The antibacterials utilization rate in patients with granulomaemia and fever without granulosis was 100% and 39.2%, respectively. The empirical application of antibacterials selection, Medication and withdrawal indications were reasonable; the existing problems were that there was no indication of prophylactic use of antibiotics (28.4%), selection of prophylactic antibacterials was irrational, and that of experiential use of antimicrobial agents was low (14.3 %). Conclusion The use of antimicrobial agents in patients with advanced breast cancer with granulomatosis in the Affiliated Tumor Hospital of Zhengzhou University is basically reasonable. However, there are still some unreasonable points which need further improvement.