ML 还不能成功地在体外培养,因此数十年来影响了对麻风的研究。本文的目的是简要评论对麻风的一些老问题用现代免疫学和 DNA 技术进行研究的状况。麻风和免疫系统一个个体对 ML 的免疫学应答在麻风的发病机理中是重要的。然而,还不清楚为什么某些个体在感染 ML 后可发病,对 ML 抗原的免疫应答形成从细胞免疫完好的结核样型麻风到细胞免疫有明显缺陷的瘤型麻风的临床病谱。所有的证据表明,结核样型麻风中巨噬细胞及来源胸腺的 T 淋巴细胞的激活 ML has not been successfully cultured in vitro and has therefore affected research on leprosy for decades. The purpose of this article is to briefly comment on the status of research on some of the old problems of leprosy using modern immunology and DNA technology. Leprosy and Immune System An immunological response to ML in an individual is important in the pathogenesis of leprosy. However, it is unclear why certain individuals develop disease after ML infection, and the immune response to the ML antigen forms a clinical spectrum of leprosy from leprous tuberculosis-like cells that are well-immunized with cells that have marked defects in cellular immunity. All evidence suggests that tuberculosis-like leprosy activates macrophages and T-lymphocytes from the thymus