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目的：观察艾司洛尔联合炙甘草汤加减治疗室性早搏的疗效。方法：选择收住入院的室性早搏患者162例，随机分为治疗组及对照组各81例，治疗组采用艾司洛尔联合炙甘草汤加减治疗；对照组采用艾司洛尔治疗，对比两组疗效及不良反应情况。结果：治疗组较对照组有效率明显升高，差异有统计学意义（P＜0.05）。用药后治疗组收缩压、舒张压及心率均较用药前降低，差异有统计学意义（P＜0.05）。治疗组较对照组血压及心率明显降低（P＜0.05）。结论：艾司洛尔联合炙甘草汤加减治疗室性早搏疗效确切，且可一定程度上降低患者血压及心率。“,”Objective: To study the effect of esmolol combined with Zhigancao Decoctioninon ventricular premature beat. Methods: The 162 patients with ventricular premature beats were randomly divided into treatment and control group, 81 cases in each. Patients were treated with esmolol combined Zhigancao Decoction in treatment group, and esmolol in control group treat-ment. The curative effect and adverse reactions were compared between the two groups. Results: The curative effect in the treat-ment group were significantly higher than that of control group, with significant difference( P<0.05). The blood pressure and heart rate in the treatment group decreased after treatment, and the difference was statistically significant ( P<0.05). The blood pressure and heart rate in the treatment group was decreased than that in the control group ( P<0.05). Conclusion: Esmolol combined Zhi-gancao Decoction can provide accurate effect for ventricular premature beat, and can reduce blood pressure and heart rate.