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特发性微小病变肾病(MCN)和局灶性节段性肾小球硬化(FSGS)被认为与T淋巴细胞功能异常有关。细胞激动素的生成紊乱导致肾小球对液体和大分子的通透性增加。目前的治疗是用类固醇激素和(或)免疫抑制药物,如苯丁酸氮芥,硫唑嘌呤和环胞素。成人常常复发,完全缓解在MCN为60％,FSGS20％。作者观察第一例MCN伴轻度肾小球膜增生的肾病综合征用哌氧沙星(Pefloxacin)治疗15天后完全缓解。该药是用于治疗葡萄球菌败血症伴发的克雷自杆菌肺炎——一种威胁生命的肺部感染。长期的类固醇加硫唑嘌呤以及环胞素治疗均未能使蛋白尿缓解,且诱发了严重的感染并发症。
Idiopathic minimal change nephropathy (MCN) and focal segmental glomerulosclerosis (FSGS) are thought to be associated with dysfunction of T lymphocytes. Disorders in the production of cytokines lead to increased glomerular permeability to liquids and macromolecules. The current treatment is with steroid hormones and / or immunosuppressive drugs such as chlorambucil, azathioprine and cyclosporine. Adults often relapse, complete remission in 60% of MCN, FSGS 20%. The authors observed a complete remission of nephrotic syndrome in the first case of MCN with mild mesangium hyperplasia after 15 days of treatment with Pefloxacin. This medicine is used to treat Staphylococcus aureus pneumonia associated with staphylococcal septicemia - a life-threatening lung infection. Long-term steroid plus azathioprine and cyclosporine treatment failed to relieve proteinuria, and induced serious complications of infection.