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目的 :对葆乐辉进行临床及血药浓度观察。方法 :混合型哮喘 11例 ,单纯过敏型哮喘 1例。 9例口服葆乐辉 40 0mg/次 ,一日一次 ,3例于首剂服用 40 0mg后因胃肠反应及 (或 )心悸而停药 ,3天后 ,再次服用2 0 0mg/次 ,一日一次。疗程均为 5天。于第 5天服药前及服药后 4小时 ,分别测定血浆茶碱浓度。结果 :于服药当天全部病例症状体征均有不同程度改善 ,试验期间症状平稳 ,无反复 ,心率稳定。日服 40 0mg者 ,其茶碱血药浓度均在药效学范围内 ;日服 2 0 0mg者 ,其茶碱血药浓度略低于药效学范围。结论 :葆乐辉具有速效、服用方便的特点。
Objective: To observe the clinical and blood concentration of Bao Lehui. Methods: 11 cases of mixed asthma and 1 case of allergic asthma alone. 9 cases of oral Bao Lehui 40 0mg / time, once a day, 3 cases in the first dose of 40 0mg due to gastrointestinal reactions and (or) palpitations and withdrawal, 3 days after taking another 200 mg / time on the 1st once. The course of treatment is 5 days. On the 5th day before taking the medicine and 4 hours after taking the medicine, the plasma theophylline concentration was determined respectively. Results: On the day of taking medicine, all the symptoms and signs of the patients were improved to some extent. During the experiment, the symptoms were stable, no recurrence and the heart rate was stable. Japanese service 40 0mg, the theophylline plasma concentrations are within the pharmacodynamic range; Japanese service 200 mg, theophylline plasma concentration slightly lower than the pharmacodynamic range. Conclusion: Bao Lehui with quick, easy to take features.