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目的探讨连续护理措施对胃癌术后围化疗期不良反应及免疫功能的影响。方法选取2010年1月至2013年1月间收治的120例术后进行化疗的胃癌患者,按照随机数字表法分成观察组和对照组,每组各60例。观察组患者采用连续护理进行干预,对照组患者采用常规护理模式进行围化疗期护理。比较两组患者围化疗期不良反应发生情况以及免疫功能的变化。结果第1个和第3个疗程结束后,观察组患者白细胞下降、恶心呕吐、肌肉关节痛、外周神经感觉异常和脱发发生率均显著低于对照组,差异均有统计学意义(均P<0.05);同化疗前相比,观察组患者化疗之后CD3+、CD4+淋巴细胞亚群数量和CD4+/CD8+均明显增高(P<0.01),同时观察组患者化疗之后CD3+、CD4+淋巴细胞亚群数量和CD4+/CD8+高于对照组,差异均有统计学意义(均P<0.01)。结论连续护理可以改善胃癌患者术后恶心、脱发以及关节疼痛等临床症状,且有助于免疫功能的恢复,值得临床推广。
Objective To investigate the effects of continuous nursing interventions on adverse reactions and immune function in patients with gastric cancer after perioperative chemotherapy. Methods A total of 120 patients with gastric cancer undergoing chemotherapy after January 2010 to January 2013 were divided into observation group and control group according to the random number table method, with 60 cases in each group. Patients in the observation group were treated with continuous nursing intervention and patients in the control group were treated with conventional nursing model in the chemotherapy-related period. The incidence of adverse reactions and the changes of immune function in the two groups during the chemotherapy were compared. Results After the first and third courses of treatment, the incidence of leukopenia, nausea and vomiting, muscle and joint pain, peripheral nerve sensation and hair loss in the observation group were significantly lower than those in the control group (all P < 0.05). Compared with those before chemotherapy, the number of CD3 +, CD4 + lymphocyte subsets and CD4 + / CD8 + in the observation group were significantly increased (P <0.01), and the number of CD3 +, CD4 + lymphocyte subsets CD4 + / CD8 + higher than the control group, the difference was statistically significant (all P <0.01). Conclusion Continuous nursing can improve the postoperative nausea, hair loss and joint pain in patients with gastric cancer and other clinical symptoms, and contribute to the recovery of immune function, worthy of clinical promotion.