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牙源性角化囊肿(OKCs)是一种好发于下颌角及升支部的发育性囊肿。与其他牙源性囊肿相比,OKCs中上皮细胞增殖活性较高、基因片断PTCH突变率高、有丝分裂计数升高,CK16、CK17、CK19等肿瘤标志物高表达。故而,认为OKCs是一良性囊性肿瘤。OKCs的诊断主要依靠影像学、病理学的检查。OKCs的治疗推荐外科的摘除术、周围骨切除术等侵袭性方法,但青年患者OKC病变涉及颌骨及牙的发育时,为了避免侵袭性方法的不良反应,袋形缝合术、减压或冲洗疗法等保守疗法在治疗OKCs中有诸多优点。
Odontogenic keratocyst (OKCs) is a developmental cyst that develops in the mandibular angle and ascending branch. Compared with other odontogenic cysts, OKCs had higher proliferation activity of epithelial cells, high mutation rate of PTCH in gene fragments, higher mitosis count and high expression of tumor markers such as CK16, CK17 and CK19. Therefore, OKCs is considered a benign cystic tumor. The diagnosis of OKCs depends mainly on imaging and pathology. The treatment of OKCs is recommended surgical methods such as surgical excision and perioperative osteotomy. However, in order to avoid the adverse reactions of invasive methods, young patients with OKC lesions involving the development of jaws and teeth, sutured bags, decompression or irrigation Conservatives and other conservative therapies have many advantages in the treatment of OKCs.