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巨大十二指肠溃疡对患者有很大危险。溃疡直径>2.5cm、溃疡侵犯十二指肠球部的80%易发生出血和穿孔。用内窥镜检查前,单用 X 线进行上消化道钡餐检查,有些患者可被误诊为十二指肠球部畸形或憩室。以 X 线和内窥镜联合检查则容易确诊。对肝转移患者采用输液泵进行肝动脉内化疗(HAIC),已成为广泛用于提高疗效和延长存活期的方法。但是,此疗法易引起上消化道合并症、胃及十二指肠的糜烂和溃疡、胆管硬化症和急性硬化性胆管炎。
Huge duodenal ulcers are very dangerous to patients. Ulcer diameter> 2.5cm, ulcer invasion of the duodenal bulb 80% prone to bleeding and perforation. Before the endoscopy, the upper digestive tract barium meal examination was performed with X-rays alone. Some patients may be misdiagnosed as duodenal bulbar malformation or diverticulum. Combined examination with X-ray and endoscope is easy to diagnose. The use of an infusion pump for intrahepatic arterial chemotherapy (HAIC) in patients with liver metastases has become a widely used method for improving efficacy and prolonging survival. However, this therapy can easily cause upper gastrointestinal complications, erosions and ulcers of the stomach and duodenum, bile duct sclerosis, and acute sclerosing cholangitis.