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对国内首次研制的钩端螺旋体外膜疫苗接种人体的反应性、血清学效果和流行病学效果进行研究。先后对两价 (含黄疸出血群赖型、七日热群七日热型 )、三价 (含黄疸出血群赖型、七日热群七日热型、流感伤寒群流感伤寒型、五价 (含黄疸出血群赖型、七日热群七日热型 ,流感伤寒群流感伤寒型、秋季热群秋季热型、犬群犬型 )外膜疫苗、菌体疫苗和安慰剂 ,分组进行全身和局部反应观察 ;并以显微镜凝集试验测定各型抗体 ;对两价外膜疫苗进行流行病学保护效果考核。结果两价和多价钩体外膜疫苗反应轻微 ,安全性良好 ;血清学效果显示 ,抗体阳转率和滴度均高于同期相应菌体疫苗诱导的同型抗体水平 2倍以上 ,提示外膜疫苗有较好的免疫原性。流行病学效果在湖北省荆州和石首两市考核 ,按血清学阳性病例统计 ,其保护率可达 95 5 7%以上。说明上述疫苗性质稳定 ,反应轻微 ,安全性良好 ,血清学效果理想 ,两价疫苗有较好的保护效果 ,可以逐步推广应用。
The reactivity, serological and epidemiological effects of Leptospira vaccine developed in China for the first time were studied. Has two pairs of (including jaundice hemorrhagic group Lai type, seven day heat group on the 7th heat), trivalent (including jaundice hemorrhagic group Lai, seven on the heat group on the 7th heat, flu typhoid influenza type, pentavalent (Including jaundice hemorrhagic group Lai type, seven-day heat group on the 7th heat-type, influenza typhoid fever group, autumn heat group autumn heat type, canine dog type) outer membrane vaccine, bacterial vaccine and placebo grouping for the whole body And local reaction were observed.The antibody of each type was determined by microscopic agglutination test and the epidemiological protective effect of bivalent vaccine was evaluated.Results The bivalent and multivalent hooks outer membrane vaccine had slight reaction and good safety.The results of serological tests , The antibody positive rate and titer were higher than the corresponding bacterial vaccine induced homotype antibody level more than 2 times, suggesting that the outer membrane vaccine has better immunogenicity.Epidemiological effects in Jingzhou and Hubei Province, Shishou City According to the statistics of seropositive cases, the protection rate can reach over 95 5 7%, indicating that the vaccine has the characteristics of stable, mild reaction, good safety and good serological effect, and the bivalent vaccine has good protective effect and can be gradually Promotion should be .