Background Patent foramen ovale (PFO)-related stroke is a possible and not easily manageable occurrence in <60-years-old patients due to the presence of different comorbidities and in particular of diastolic dysfunction which is considered as a contraindication to PFO closure. The grade of diastolic dysfunction for which PFO closure is contraindicated and whether there are changes in diastolic dysfunction class after closure have not been investigated in deep yet. Methods We prospectively enrolled patients who were referred to our centre over a 12 months period for PFO transcatheter closure having echocardiographic demonstration of diastolic dysfunction (< Ⅲ class diastolic dysfunction). Echocardiography was scheduled at 1, 6 and 12 months in order to assess changes in haemodynamic parameters of left ventricle function. Results Thirteen out of 80 patients referred to our centre (16.2%, mean age 65 ± 6.4 years) over a 24-month period were enrolled in the study (Table 1). Eighteen Amplatzer PFO Occluder 25 mm and one 35 mm, two Amplatzer 25/ 25 mm Cribriform Occluder and two 25 mm Premere Occlusion System were successfully implanted with no intraoperative complications. As collateral findings on ICE 8/12 patients (66.7 %) had hypertrophy of the interatrial septum (thickness of the rims >1.2 mm) probably imputable to hypertensive cardiomyopathy. Four patients developed atrial fibrillation during the first month post-implantation, all successfully treated with antiarrhythmic drugs. After a mean follow-up of 40±4.3 months left ventricle performance indices (ejection fraction and end-diastolic volume) and diastolic dysfunction parameters (E/A, deceleration time, diastolic dysfunction class) did not change significantly. Conclusion The present study suggests that PFO transcatheter closure may be safely performed in agedpatients with diastolic dysfunction class 1-2. Background Patent foramen ovale (PFO) -related stroke is a possible and not easily manageable occurrence in <60-years-old patients due to the presence of different comorbidities and in particular of diastolic dysfunction which is considered as a contraindication to PFO closure. grade of diastolic dysfunction for which are changes in diastolic dysfunction class after closure have not been investigated in deep yet. Methods We prospectively enrolled patients who were referred to our center over a 12-month period for PFO transcatheter closure having Echocardiographic demonstration of diastolic dysfunction (<¢ ó class diastolic dysfunction). Echocardiography was scheduled at 1, 6 and 12 months in order to assess changes in haemodynamic parameters of left ventricle function. Results Thirteen out of 80 patients referred to our center (16.2% mean age 65 ± 6.4 years) over a 24-month period were enrolled in the study (Table 1). Eighteen Amp latocol PFO Occluder 25 mm and one 35 mm, two Amplatzer 25/25 mm Cribriform Occluder and two 25 mm Premere Occlusion System were successfully implanted with no intraoperative complications. As collateral findings on ICE 8/12 patients (66.7%) had hypertrophy of the All patients treated with antiarrhythmic drugs. After a mean follow-up of 40 ± 4.3 months left ventricle performance indices (ejection fraction and end-diastolic volume) and diastolic dysfunction parameters (E / A, deceleration time, diastolic dysfunction class) did not change significantly. Conclusion The present study suggests that PFO transcatheter closure may be safely performed in agedpatients with diastolic dysfunction class 1-2.