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目的观察过敏史对婴幼儿首次及第2次哮喘急性期血清白三烯浓度有无影响。方法收集2008年11月至2009年3月在大连市儿童医院呼吸病房住院、临床确诊为婴幼儿早期哮喘的患儿138例。其中首次哮喘(毛细支气管炎)72例,有过敏史51例,无过敏史21例;第2次哮喘66例,其中有过敏史57例,无过敏史9例。对138例均进行血清白三烯检测,观察两组中过敏史对血白三烯浓度有无影响,并比较两组过敏史的发生率。结果首次哮喘中,有过敏史与无过敏史患儿血清白三烯浓度差异无统计学意义(P>0.05);第2次哮喘中,有过敏史血清白三烯与无过敏史血清白三烯浓度差异也无统计学意义(P>0.05)。第2次哮喘中过敏史率明显高于首次哮喘(P<0.05)。结论过敏史对婴幼儿首次及第2次哮喘急性期血清白三烯浓度无明显影响,但第2次哮喘中过敏史发生率明显高于首次哮喘,说明有过敏史的患儿更易发生反复哮喘。
Objective To investigate the history of allergy in infants with first and second acute asthma serum leukotriene concentration has no effect. Methods A total of 138 children admitted to Respiratory Unit in Children’s Hospital of Dalian City from November 2008 to March 2009 were collected and clinically diagnosed as early stage asthma in infants and young children. The first asthma (bronchiolitis) in 72 cases, allergic history in 51 cases, no allergic history in 21 cases; the second asthma in 66 cases, of which 57 cases of allergy, allergy history in 9 cases. Serum leukotriene was detected in 138 cases. The history of allergy in both groups was observed whether leukotriene concentration was affected or not, and the incidence of allergy history was compared between the two groups. Results In the first asthma, there was no significant difference in serum leukotriene between allergic history and no history of allergy (P> 0.05). In the second asthma, There was also no significant difference in the concentration of olefins (P> 0.05). The second allergic history of asthma was significantly higher than the first-time asthma (P <0.05). Conclusion The history of allergy has no effect on serum leukotriene concentrations in the first and second asthma acute asthma in infants. However, the incidence of allergy in the second asthma is significantly higher than that in the first asthma, indicating that children with allergies are more likely to have recurrent asthma .