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目的观察调经助孕方联合二甲双胍治疗多囊卵巢综合征(PCOS)的临床疗效。方法将60例PCOS患者随机分为3组,每组20例。中药组服用调经助孕方,西药组服用二甲双胍,中西药联合组(联合组)同时服用以上两种药物,观察6个月经周期。观测3组患者体重指数(BMI)、腰臀比(WHR)、Ferriman-Gallwey多毛评分(F-G评分)、月经情况、性激素和胰岛抵抗指数(HOMA-IR)的变化。结果联合组可以降低PCOS患者BMI、WHR及黄体生成素(LH)、睾酮(T)、LH/卵泡刺激素(FSH)、HOMA-IR水平(P<0.05),改善月经,对F-G评分、FSH改善不明显(P>0.05)。其中在改善月经方面优于西药组(P<0.05),在改善LH、HOMA-IR方面优于中药组(P<0.05),在改善T、LH/FSH方面疗效优于西药组和中药组(P<0.05);联合组临床疗效优于西药组和中药组(P<0.05)。结论调经助孕方与二甲双胍联合治疗是临床治疗多囊卵巢综合征的较优组合。
Objective To observe the clinical effect of twentysomethral syndrome (PCP) combined with metformin on menstruation and menstruation. Methods Sixty PCOS patients were randomly divided into three groups (20 in each group). The traditional Chinese medicine group took the prescription of regulating menstruation and pregnant and the western medicine group took metformin. The combination of traditional Chinese and western medicine (combination group) took the above two drugs at the same time and observed 6 menstrual cycles. The changes of body mass index (BMI), WHR, Ferriman-Gallwey hairy index (F-G), menstrual status, sex hormone and insulin resistance index (HOMA-IR) were observed in the three groups. Results The combination group could reduce the levels of BMI, WHR, LH, T, LH / HOMA-IR and improve menstruation in PCOS patients Improvement is not obvious (P> 0.05). The improvement of LH, HOMA-IR was better than that of traditional Chinese medicine group (P <0.05), and the improvement of T, LH / FSH was better than that of Western medicine group and traditional Chinese medicine group P <0.05). The clinical efficacy of combination group was better than western medicine group and traditional Chinese medicine group (P <0.05). Conclusion The combination of Tiaojing Recipe and metformin is a better combination of clinical treatment of polycystic ovary syndrome.