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为探讨椎间盘源性腰腿痛的病理机制及腰腿痛胶囊对自体髓核硬膜外移植大鼠神经根功能恢复的影响 ,将 4 8只健康、雄性大鼠 ,随机分成假手术组 (SG)、对照组 (MG)、腰腿痛胶囊低剂量组 (LG)、腰腿痛胶囊高剂量组 (HG组 ) ,每组 12只。在麻醉下 ,各组动物距肛门 1cm处截断尾骨 ,SG组仅咬除右侧半椎板 ,显露L5神经根 ;其余各组皆取自体尾椎髓核 (约 10mg)植入右侧L5神经根背侧。分别在术后第 7、14、2 8天检测大鼠马尾神经MEP、SEP。结果显示 ,SG组手术前后诱发电位的改变无统计学意义 ;MG组术后波幅降低 ,潜伏期延长 ,术后 14天波幅下降最低 ,潜伏期延长最明显 ;LG组术后 7和 14天、HG组术后 7天波幅下降 ,潜伏期延长 ,与自身术前比较差异显著 (P <0 .0 5或P <0 .0 1) ;LG组移植术后 2 8天、HG组 14天马尾神经诱发电位开始恢复。表明在无明显机械压迫情况下 ,大鼠自体尾椎髓核移植硬膜外腔造成了脊神经根结构与功能损害 ,腰腿痛胶囊可减轻或延缓该损伤。可能是通过降低神经根局部组织的炎性介质和 (或 )自身免疫反应而起作用
To investigate the pathological mechanism of lumbar and lumbar disc herniation and the effect of lumbar leg pain capsule on the recovery of nerve root function in rats transplanted with autologous nucleus pulposus, 48 healthy and male rats were randomly divided into sham operation group (SG). ), Control group (MG), low-lumbar pain capsule low-dose group (LG), low-back leg pain capsule high-dose group (HG group), 12 in each group. Under anesthesia, each group of animals cut off the coccyx 1cm from the anus. The SG group only bite the right hemi-laminate to expose the L5 nerve root. The rest of the groups were taken from the caudate nucleus pulposus (about 10mg) to implant the right L5 nerve. Root back side. The rat tail nerve MEP and SEP were detected on the 7th, 14th, and 28th days after operation. The results showed that there was no significant difference in evoked potentials before and after surgery in the SG group. The amplitude of the evoked potentials in the SG group was decreased, and the latency was prolonged. The amplitude of the 14th day postoperatively was the lowest and the latency was most prolonged. The LG group was postoperative 7 and 14 days, and the HG group. At 7 days postoperatively, the wave amplitude decreased and the latency period prolonged, which was significantly different from that before operation (P <0.05 or P <0.01). The evoked potentials of cauda equina nerve in the LG group were 28 days after transplantation and 14 days after HG. Start recovery. It was shown that transplanting autogenous caudal nucleus pulposus into the epidural space resulted in structural and functional damage to the spinal nerve roots in the absence of significant mechanical compression. Lumbar and leg pain capsules can reduce or delay the injury. May work by reducing the inflammatory mediators and/or autoimmune responses of local tissues of nerve roots.