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目的探讨多西紫杉醇联合顺铂治疗晚期食道癌的疗效及毒副反应。方法入组26例病理诊断的食道癌应用多西紫杉醇联合顺铂方案(多西紫杉醇60mg第1、8天+顺铂40mg第2～4天)化疗2个周期以上评价疗效。结果CR1例,PR14例,NC6例,PD5例,临床有效率(CR+PR)57.7%。主要不良反应是可逆性的骨髓抑制和胃肠反应,Ⅲ、Ⅳ度少见,未见明显肝肾毒性。结论多西紫杉醇联合顺铂治疗国人晚期食道癌疗效和安全性均较好,毒性反应可以耐受,值得进一步研究和观察。
Objective To investigate the efficacy and side effects of docetaxel combined with cisplatin in the treatment of advanced esophageal cancer. Methods 26 patients with pathologically diagnosed esophageal cancer were treated with docetaxel combined with cisplatin (docetaxel 60mg day 1,8 + cisplatin 40mg day 2 ~ 4) chemotherapy for more than 2 cycles to evaluate the efficacy. Results CR1 cases, PR14 cases, NC6 cases, PD5 cases, clinical effective rate (CR + PR) 57.7%. The main adverse reactions are reversible myelosuppression and gastrointestinal reactions, Ⅲ, Ⅳ degrees rare, no significant liver and kidney toxicity. Conclusion Docetaxel combined with cisplatin in the treatment of advanced esophageal cancer in our country has good efficacy and safety, and the toxicity can be tolerated. It is worth further study and observation.