氯墜啉引起咀嚼肌运动显著障碍者尚属少見。茲报告1例如下:患者(住院号1850)男,35岁,干部,1963年11月13日入院。緣于1960年因受凉后全身出現水肿,某医院診断为“腎炎”,住院治疗半年后,水肿漸涫失,蛋白尿((?)—(?))无变化。近几年来,自觉体力漸弱,經常头暈,伹无尿頻、尿疼及少尿現象,因不能坚持工作而入我院。既往无下頜关节习慣性脫臼及服用氯喹啉史。入院检查符合慢性腎炎、腎变性型診断。入院后曾采用大剂量路丁,双氢克尿塞,中药,激素等治疗,并配合低鈉飲食,均未見疗效。1964年10月16日开始給予氯喹啉0.25克,一日两次,四天后出現咀嚼肌疲劳,嚼物困难,进食外流,下頜时常不能提起,因而造成吞咽和言談的困难,每次进餐需很长时間。并需休息数次。上述情况日漸加重,并出現輕度視力模糊。下頜关节不痛,检查也无特殊,面部表情及肌肉运动正常,口腔粘膜、咽部、扁桃体、牙齿、齿齦、软顎与舌的屈伸运动等均无异常发現。肌张力、脏反射、心肺也无改变。停药四天后上述現象逐渐消失。一周后又給予氯喹啉,用量及方法同上,三天后又出現上述現象。血尿常規和胆固醇等检查結果仍如前,未見好轉,血鉀20毫克％,心电图未表示有缺鉀現象。停药后又逐步緩解,六天后全部消失。討論:氯喹啉在长期应用大剂量时易于产生副作用,可能影响神輕与肌肉的功能,但本例用药仅四天,用量不大,且腎功能尚正常,即出現明显咀嚼肌运动障碍,两次 Chlorpheniramine caused masticatory muscle movements were significantly impaired persons is still rare. We hereby report a case as follows: Patient (hospital number 1850) Male, 35 years old, cadre, admitted to hospital on November 13, 1963. Due to the systemic edema after cold in 1960, a hospital diagnosed as “nephritis”. After six months of hospitalization, the edema gradually disappeared and the proteinuria ((?) - (?)) Did not change. In recent years, consciously fatigued, often dizzy, no urinary frequency, urinary pain and oliguria phenomenon, because they can not adhere to work into our hospital. Past non-mandibular habitual dislocation and taking chloroquine history. Admission check with chronic nephritis, renal degeneration diagnosis. Admitted to high-dose road after d, hydrochlorothiazide, traditional Chinese medicine, hormones and other treatment, and with low-sodium diet, no efficacy. On October 16, 1964, 0.25 grams of chloroquine was given twice a day. After four days, masticatory muscle fatigue, difficulty in eating chewing, outflow from the jaw, and difficulty in lifting the jaw often resulted in difficulties in swallowing and talking Long time. And need to rest several times. The above situation is getting worse with mild blurred vision. Mandibular joint pain, no special examination, facial expression and muscle movement is normal, oral mucosa, pharynx, tonsils, teeth, gums, soft jaw and tongue flexion and extension movements were found no abnormalities. Muscle tension, dirty reflection, heart and lung have not changed. Four days after discontinuation of the above-mentioned phenomena gradually disappear. A week later give chloroquine, the amount and method Ibid three days after the above-mentioned phenomenon. Hematuria and cholesterol test results are still the same as before, no improvement, 20 mg potassium, electrocardiogram did not show the phenomenon of potassium deficiency. After withdrawal and gradually alleviate, all disappeared after six days. Discussion: Chloroquinoline prone to side effects in the long-term high-dose, may affect the function of light and muscle, but this case medication only four days, the amount is not large, and renal function is still normal, that there was significant masticatory muscle dyskinesia, two Times